I am a postdoctoral fellow at the New York Genome Center, advised by Dr. Rahul Satija and Dr. David Knowles, and supported by the Damon Runyon Quantitative Biology fellowship. In 2023, I received my PhD in Biostatistics at Harvard University, under the joint supervision of Dr. Rafael Irizarry and Dr. Giovanni Parmigiani. Previously, I earned a Bachelor’s degree in Chemical & Biological Engineering from Princeton University. I develop statistical and machine learning frameworks for genomics data, with special interest in how we can leverage massive, underutilized data resources.
“Mapping transcriptional responses to cellular perturbation dictionaries with RNA fingerprinting”. Isabella N. Grabski, Junsuk Lee, John Blair, Carol Dalgarno, Isabella Mascio, Alexandra Bradu, David A. Knowles, Rahul Satija. bioRxiv (in revision at Cell). (2025)
“Bayesian multi-study non-negative matrix factorization for mutational signatures”. Isabella N. Grabski, Lorenzo Trippa, Giovanni Parmigiani. Genome Biology. (2025)
“Significance analysis for clustering with single-cell RNA-sequencing data”. Isabella N. Grabski, Kelly Street, Rafael A. Irizarry. Nature Methods. (2023)
“Bayesian combinatorial multi-study factor analysis”. Isabella N. Grabski, Roberta De Vito, Lorenzo Trippa, Giovanni Parmigiani. Annals of Applied Statistics. (2023)
“A probabilistic gene expression barcode for annotation of cell-types from single cell RNA-seq data”. Isabella N. Grabski, Rafael A. Irizarry. Biostatistics. (2022)
“Iterative, multimodal, and scalable single-cell profiling for discovery and characterization of signaling regulators”. John D. Blair, Alexandra Bradu, Carol Dalgarno, Isabella N. Grabski, Rahul Satija. bioRxiv. (2025)
“Bayesian probit multi-study non-negative matrix factorization for mutational signatures”. Blake Hansen, Isabella N. Grabski, Giovanni Parmigiani, Roberta De Vito. arXiv. (2025)
“Baseline immune state and T-cell clonal kinetics are associated with durable response to CAR-T therapy in large B-cell lymphoma”. A. Katie Maurer*, Isabella N. Grabski*, Roch Houot*, Satyen H. Gohil*, Shogo Miura, Robert Redd, Haoxiang Lyu, Wesley Lu, Yohei Arihara, Justin Budka, Mikaela McDonough, Michela Ansuinelli, Carol Reynolds, Heather Jacene, Shuqiang Li, Kenneth J. Livak, Jerome Ritz, Brodie Miles, Mike Mattie, Donna S. Neuberg, Rafael A. Irizarry, Philippe Armand, Catherine J. Wu, Caron Jacobson. Blood. (2024)
“Effects of KRAS genetic interactions on outcomes in cancers of the lung, pancreas, and colorectum”. Isabella N. Grabski, John V. Heymach, Kenneth L. Kehl, Scott Kopetz, Ken S. Lau, Gregory J. Riely, Deborah Schrag, Rona Yaeger, Rafael A. Irizarry, Kevin M. Haigis. Cancer Epidemiology, Biomarkers, & Prevention. (2024)